Araştırma

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             Obsesif Kompulsif Bozukluk 

 

  • Obsesif kompulsif bozukluğu olan hastaların ve kardeşlerinin model tabanlı öğrenme ile ilişkili frontostriatal beyin yapılarının araştırılması. Sci Rep. 2021,

  • Otizmli çocukların anne ve kardeşlerinde obsesif kompulsif bozukluk ile ilişkili etmenler. Noro Psikiyatr Arşivi. 2018 

  • Bilişsel Nöropsikolojik model bağlamında obsesif kompulsif bozuklukta tedavi yanıtını ve direncini anlamak. Turk Psikiyatri Derg. 2016

  • Farmakolojik tedavinin obsesif kompulsif bozuklukta obsesif inanışlara etkisi. European Psychiatry. 2011.

  • Obsesif kompulsif bozuklukta sağlık yardımı arama davranışı ile ilişkili etmenler. Çok boyutlu bir yaklaşım. Türk pSikiyatri Dergisi 2006.

  • Obsesif kompulsif bozukluğu olan gençler ve annelerinin bilişsel bilişsel süreçleri arasındaki ilişki. Compr Psychiatry. 2013

  • Obsesif kompulsif bozuklukta çocukluk çağı travmaları Relations between childhood traumatic experiences, çözülme ve bilişsel modeller araasındaki ilişki  International Journal of Psychiatry in Clinical Practice. 2012

  • Otojen ve reaktif obsesif kompulsif belirtileri olan hastalarda farklı nöral sistemlerin tutulumu. Acta Psychiatrica Scandinavica, 2011

  • Obsesif kompulsif bozuklukta antidepresan tedavinin düşünce eylem füzyonu ve üst biliş sistemlerine etkisi  Comprehensive Psychiatry 2011.

Örnek Araştırmalarım

 

 

 

Klinik deneyimim büyük oranda ayaktan hasta ve klinik ortamda  yatan hastaların takibi ile gelişirken akademik kimliğim bu uygulamaların bilimsel nitelikte olmasına zemin hazırlamıştır. Özellik takıntı bozukluğu olarak bilinen OBSESİF KOMPULSİF BOZUKLUK (takıntı yada titizlik hastalığı) başta olmak üzere bir çok alanda araştırmaları planladım, organize ettim ve yayınladım.  Bu alanlar DEPRESYON, ANKSİYETE BOZUKLUKLARI, UYKU BOZUKLUKLARI, PSİKOLOJİK TRAVMA ve daha başka hastalık ve sorunları da  içermektedir.

TÜM ARAŞTIRMALAR 

 

ULUSLARARASI HAKEMLİ DERGİLERDE YAYINLANAN MAKALELER

(SCI & SSCI & ARTS AND HUMANITIES) 

 

 

  1. Kasal MI, Besiroglu L, Zorlu N, Dikmeer N, Bilge A, Durmaz E, Polat S, Gelal F, Rapp M, Heinz A, Sebold M. Fronto-striatal structures related with model- based control as an endophenotype for obsessive-compulsive disorder. Sci Rep. 2021 
  2. Dikmeer N, Besiroglu L, Di Biase MA, Zalesky A, Kasal MI, Bilge A, Durmaz E, Polat S, Gelal F, Zorlu N. White matter microstructure and connectivity in patients with obsessive-compulsive disorder and their unaffected siblings. Acta Psychiatr Scand. 2021 
  3. Uzer T, Beşiroğlu L, Karakılıç M. Event centrality, transitional impact and symptoms of posttraumatic stress in a clinical sample. Anxiety Stress Coping. 2020 
  4. Saricicek Aydogan A, Oztekin E, Esen ME, Dusmez S, Gelal F, Besiroğlu L, Zorlu N. Cortical thickening in remitters compared to non-remitters with majör depressive disorder following 8-week antidepressant treatment. Acta Psychiatr Scand. 2019 
  5. Kilicaslan EE, Türe HS, Kasal Mİ, Çavuş NN, Akyüz DA, Akhan G, Besiroglu L. Differences in obsessive-compulsive symptom dimensions between patients with epilepsy with obsessive-compulsive symptoms and patients with OCD. Epilepsy Behav. 2020 
  6. Altas EU, Askin A, Beşiroğlu L, Tosun A. Is high-frequency repetitive transcranial magnetic stimulation of the left primary motor cortex superior to the stimulation of the left dorsolateral prefrontal cortex in fibromyalgia syndrome? Somatosens Mot Res. 2019 
  7. Özyurt G, Beşiroğlu L. Autism Spectrum Symptoms in Children and Adolescents with Obsessive Compulsive Disorder and Their Mothers. Noro Psikiyatr Ars. 2018 
  8. Boysan M, Yıldırım A, Beşiroğlu L, Kefeli MC, Kağan M. Development and Preliminary Psychometric Properties of an Instrument for the Measurement of Obsessional Dissociative Experiences: The Van Obsessional Dissociation Questionnaire (VOD-Q). Psychiatr Q. 2018 
  9. Zorlu N, Çapraz N, Oztekin E, Bagci B, Di Biase MA, Zalesky A, Gelal F, Bora E, Durmaz E, Beşiroğlu L, Sarıçiçek A. Rich club and reward network connectivity  as endophenotypes for alcohol dependence: a diffusion tensor imaging study. Addict Biol. 2017 
  10. Zorlu N, Angelique Di Biase M, Kalaycı ÇÇ, Zalesky A, Bağcı B, Oğuz N, Gelal F, Beşiroğlu L, Gülseren Ş, Sarıçiçek A, Bora E, Pantelis C. Abnormal White matter integrity in synthetic cannabinoid users. Eur Neuropsychopharmacol. 2016 
  11. Beşiroğlu L. Understanding Treatment Response and Resistance in Obsessive Compulsive Disorder in the Context of Cognitive Neuropsychological Model. Turk Psikiyatri Derg. 2016 
  12. Güler AS, do Rosário MC, Ayaz AB, Gökçe S, Yulaf Y, Başgül S, Özcan Ö, Karabekiroğlu K, Munir K, Beşiroğlu L, Yazgan Y. Psychometric properties of the DY-BOCS in a Turkish sample of children and adolescents. Compr Psychiatry. 2016
  13. Güleç M, Deveci E, Beşiroğlu L, Boysan M, Kalafat T, Oral E. Development of a Psychometric Instrument Based on the Inference-Based Approach to Obsessive-Compulsive Disorder: The Obsessional Probabilistic Inference Scale. Noro Psikiyatr Ars. 2014 
  14. Aydin A, Boysan M, Kalafat T, Selvi Y, Beşiroğlu L, Kagan M. Validation of the Turkish Version of the Obsessive-Compulsive Inventory-Revised (OCI-R) in Clinical and Non-Clinical Samples. Noro Psikiyatr Ars. 2014; 
  15. Besiroglu L, Karaca S, Keskin I. Scrupulosity and obsessive compulsive disorder. The cognitive perspective in Islamic sources. Journal of Health and Religion. 2014
  16. Aydin A, Selvi Y, Besiroglu L, Boysan M, Atli A , Ozdemir O, Balaharoglu R. Mood and metabolic consequences of sleep deprivation as a potential endophenotype’in bipolar disorder. Journal of Affective disorders. 2013
  17. Kadak MT, Balsak F, Besiroglu L, Celik C. Relationships between cognitive appraisals of adolescents with OCD and their mothers. Compr Psychiatry. 2013 
  18. Gulec M, Ozkol H, Selvi Y, Tuluce Y, Aydin A, Besiroglu L, Ozdemir PG. Oxidative stress in patients with primary insomnia. Prog Neuropsychopharmacol Biol Psychiatry, 2012
  19.  Aydin A, Gulec M, Boysan M, Selvi Y, Selvi F, Kadak MT, Besiroglu L. Seasonality of self-destructive behaviour: Seasonal variations in demographic and suicidal characteristics in Van, Turkey. Int J Psychiatry Clin Pract. 2012.
  20. Ozdemir PG, Selvi Y, Ozkol H, Aydın A, Tülüce Y, Boysan M, Beşiroğlu L. The influence of shift work on cognitive functions and oxidative stress. Psychiatry Res. 2013 
  21. Aydın A, Gumrukcuoglu HA, Selvi Y, Besiroglu L, Ozdemir P, Ozdemir O, Akdag S, Cegin B. Alterations in p wave duration and dispersion in depressive patients following electroconvulsive therapy. Gen Hosp Psychiatry 2012.
  22. Ozdemir O, Selvi Y, Ozkol H, Tuluce Y, Besiroglu L, Aydin A. Comparison of superoxide dismutase, glutathione peroxidase and adenosine deaminase activities between respiratory and nocturnal subtypes of patients with panic disorder. Neuropsychobiology. 2012
  23. Gulec M, Selvi Y, Boysan M, Aydin A, Besiroglu L, Agargun MY. Socio-demographic and clinical risk factors on the non-recovery of the major depressive disorder: a 52-week follow-up study. European Psychiatry. 2012
  24. Selvi Y, Besiroglu L, Aydin A, Gulec M, Atli A, Boysan M, Celik C. Relations between childhood traumatic experiences, dissociation, and cognitive models in obsessive compulsive disorder. International Journal of Psychiatry in Clinical Practice. 2012
  25. Aydın A, Barut Y, Kalafat T, Boysan M, Beşiroğlu L. Psychometric properties of the Turkish version the PTSD symptom scale-self-report. Anatolian Journal of Psychiatry 201.
  26. Selvi Y, Besiroglu L, Aydin A, Atli A, Gulec M. Influence Of Pharmacological Treatment On Obsessive Beliefs In The Patients With Obsessive Compulsive Disorder, European Psychiatry. 2011; 26: 979-979. (SCI, SCI-EXP, SSCI)
  27. Besiroglu L, Sozen M, Ozbebit O, Avcu S, Selvi Y, Bora A, Atli A, Unal O, Bulut MD. The involvement of distinct neural systems in patients with obsessive-compulsive disorder with autogenous and reactive obsessions. Acta Psychiatrica Scandinavica 2011.
  28. Besiroglu L, Cetinkaya N, Selvi Y, Atli A. Effects of selective serotonin reuptake inhibitors on thought-action fusion, metacognitions, and thought suppression in obsessive-compulsive disorder. Comprehensive Psychiatry 2011
  29. Gulec M, Selvi Y, Boysan M, Aydin A, Besiroglu L, Agargun MY. Ongoing or re-emerging subjective insomnia symptoms after full/partial remission or recovery of major depressive disorder mainly with the selective serotonin reuptake inhibitors and risk of relapse or recurrence: A 52-week follow-up study. Journal of Affective Disorders 2011.
  30. Selvi Y, Özkol H, Tuluce Y, Besiroglu L, Ozdemir PG. Chronotypes and oxidative stress: is there an association? Biologicl Rhythm Research 2011.
  31. Selvi Y, Aydin A, Gulec M, Boysan M, Besiroglu L, Ozdemir PG, Kilic S. Comparison of dream anxiety and subjective sleep quality between chronotypes. Sleep and Biological Rhythms 2011.
  32. Selvi Y, Aydin A, Gumrukcuoglu HA, Gulec M, Besiroglu L, Ozdemir PG, Kilic S. Dream Anxiety is an emotional trigger for acute myocardial infarction. Psychocomatics 2011.
  33. Selvi Y, Atli A, Journal of Psychiatry in Clinical Practic.e Besiroglu L, Aydin A, Gulec M.  The Impact of obsessive beliefs on pharmacological treatment response in patients with obsessive-compulsive disorder. International Journal of Psychiatry in Clinical Practice 2011
  34. Selvi Y, Ozturk RI, Agargun MY, Besiroglu L, Cilli AS. Temel yas unsurlari olcegi Turkce formunun gecerlik ve guvenirlik calismasi. Archives of Neuropsychiatry. 2011
  35. Selvi Y, Atli A, Aydin A, Besiroglu L, Ozdemir P, Ozdemir O. The comparison of aripiprazole and risperidone augmentation in selective serotonin reuptake inhibitor-refractory obsessive-compulsive disorder: a single-blind, randomised study. Human Psychopharmacology 2011
  36. Selvi Y, Smolensky MH, Boysan M, Aydin A, Besiroglu L, Atli A, Gumrukcuoglu HA. Role of patient chronotype on circadian pattern of myocardial infarction: a pilot study. Chronobiology International 2011
  37. Selvi Y, Aydin A, Atli A, Boysan M, Selvi F, Besiroglu L. Chronotype differences in suicidal behavior and impulsivity among suicide attempters. Chronobiology International 2011.
  38. Özdemir O, Polat FH, Beşiroğlu L, Selvi Y, Özdemir P, Atlı A, Akbayram S. Traumatic experiences, dissociation and attitudes toward delinquency in the juvenile male delinquents. Anatolian Journal of Psychiatry 2011; 12(1): 68-75. (SCI-EXP)
  39. Boysan M, Beşiroğlu L, Çetinkaya N, Atlı A, Aydın A. the validity and reliability of the turkish version of the Obsessive Beliefs Questionnaire-44 (OBQ-44) Archives of Neuropsychiatry 2010; 47(3): 216-22. (SCI-EXP)
  40. Boysan M, Güleç M, Beşiroğlu L, Kalafat T. Psychometric properties of the Insomnia Severity Index in Turkish sample. Anatolian Journal of Psychiatry 2010; 11(3): 248-52. (SCI-EXP)
  41. Beşiroğlu L, Akman N, Selvi Y, Aydın A, Boysan M, Özbebit Ö. Mental health literacy concerning categories of obsessive-compulsive symptoms. Archives of Neuropsychiatry 2010; 47(2): 133-8. (SCI-EXP)
  42. Selvi Y, Aydin A, Boysan M, Atli A, Agargun MY, Besiroglu L. Associations between chronotype, sleep quality, suicidality, and depressive symptoms in patients with major depression and healthy controls. Chronobiology International 2010; 27(9-10): 1813-28. (SCI, SCI-EXP)
  43. Besiroglu L, Akdeniz N, Agargun M , Calka O, Ozdemir O, Bilgili SG. Childhood traumatic experiences, dissociation and thought suppression in patients with Psychosomatic skin diseases. Stress and Health 2009: 25; 121-5. (SCI, SCI-EXP)
  44. Boysan M, Beşiroğlu L, Kalafat T, Kağan M, Ateş C. Associations of dysfunctional interpersonal schemas with obsessive-compulsive and dissociative symptoms in university students. Archives of Neuropsychiatry 2010; 47(1): 9-14. (SCI-EXP)
  45. Selvi Y, Aydın A, Beşiroğlu L. Atypical Psychiatric Symptoms Associated with Left Temporal Lesion: Two Cases. Bulletin of Clinical Psychopharmacology 2010; 20(4): 329-33. (SCI-EXP)
  46. Uğuz F, Beşiroğlu L, Aşkın R. Sociodemographic and clinical characteristics in patients with obsessive-compulsive disorder with and without comorbid obsessive-compulsive personality disorder. Anatolian Journal of Psychiatry 2009
  47. Besiroglu L, Akdeniz N, Agargun MY, Calka O, Ozdemir O, Bilgili SG. Childhood traumatic experiences, dissociation and thought suppression in patients with ‘Psychosomatic’skin diseases. Stress and Health. 2009.
  48. Beşiroğlu L, Güleç M, Kıran SG, Polat N. Cerebellar cognitive affective syndrome: A case report. Bulletin of Clinical Psychopharmacology 2008
  49. Çelikel H, Beşiroğlu L. Childhood traumatic experiences, dissociation and obsessive-compulsive symptoms in non-clinical samples. Anatolian Journal of Psychiatry 2008.
  50. Boysan M, Keskin S, Beşiroğlu L. Assessment of hierarchical factor structure, reliability and validity of penn state worry questionnaire Turkish version. Bulletin of Clinical Psychopharmacology 2008
  51. Boysan M, Beşiroğlu L, Kara H, Kayrı M, Keskin S. Associations between the levels of depression and the sense of limitedness: a psychometric analysis. Anatolian Journal of Psychiatry 2008
  52. Boysan M, Beşiroğlu L, Kara H, Kayrı M, Keskin S. Associations between the levels of depression and the sense of limitedness: a psychometric analysis. Anatolian Journal of Psychiatry 2008
  53. Beşiroğlu L, Ağargün MY, Boysan M, Güleç M, Eryonucu B. The psychometric properties of the Clark-Beck Obsessive- Compulsive Inventory in a Turkish population. Anatolian Journal of Psychiatry 2007
  54. Beşiroğlu L, Uğuz F, Sağlam M, Yılmaz E, Ağargün MY, Aşkın R. Factors associated with quality of life in obsessive compulsive disorder. Anatolian Journal of Psychiatry 2007
  55. Beşiroğlu L, Uğuz F, Sağlam M, Ağargün MY, Aşkın R, Çilli AS. Psychopharmacological treatment response in obsessive compulsive patients with autogenous and reactive obsessions. Bulletin of Clinical Psychopharmacology 2007
  56. Beşiroğlu L, Ağargün MY, Ozbebit O, Sözen M, Dilek I, Güleç M. Therapeutic response to plasmapheresis in four cases with obsessive-compulsive disorder and tic disorder triggered by streptococcal infections. Turk Psikiyatri Derg 2007
  57. Besiroglu L, Uguz F, Saglam M, Agargun MY, Cilli AS. Factors associated with major depressive disorder occurring after the onset of obsessive-compulsive disorder. Journal of Affective Disorders 2007
  58. Selvi Y, Gülec MY, Boysan M, Agargun MY, Besiroglu L. Mood changes after sleep deprivation in morningness-eveningness chronotypes in healthy individuals, Journal Of Sleep Research. 2007
  59. Besiroglu L, Uguz F, Ozbebit O, Guler O, Cilli AS, Askin R. Longitudinal assessment of symptom and subtype categories in obsessive-compulsive disorder. Depression and Anxiety. 2007.
  60. Agargun MY, Besiroglu L, Cilli AS, Gulec M, Aydin A, Inci R, Selvi Y. Nightmares, suicide attempts, and melancholic features in patients with unipolar major depression. Journal of Affective Disorders 2007
  61. Besiroglu L, Agargun MY, Ozbebit O, Aydin A. A discrimination based on autogenous versus reactive obsessions in obsessive-compulsive disorder and related clinical manifestations. CNS Spectrums 2006
  62. Uguz F, Askin R, Cilli AS, Besiroglu L. Comparison of treatment responses and clinical characteristics of early-onset and late-onset obsessive-compulsive disorder. International journal of psychiatry in clinical practice. 2006.
  63. Beşiroğlu L, Ağargün MY. The correlates of healthcare seeking behavior in obsessive-compulsive disorder: a multidimensional approach. Turk Psikiyatri Derg 2006
  64. Beşiroğlu L, Yücel Ağargün M, Boysan M, Eryonucu B, Güleç M, Selvi Y. The assessment of obsessive-compulsive symptoms: the reliability and validity of the Padua inventory in a Turkish population. Turk Psikiyatri Derg. 2005.
  65. Ağargün MY, Beşiroğlu L, Kıran ÜK, Özer ÖA, Kara H. The psychometric properties of the COPE inventory in Turkish sample: a preliminary research. Anatolian Journal of Psychiatry 2005.
  66. Ağargün MY, Beşiroğlu L, Kemal KU, Kara H, Akil Ozer O. The reliability and validity of the White Bear Suppression Inventory. Turk Psikiyatri Derg. 2004
  67. Beşiroğlu L, Özer ÖA, Bal AC, Sağlam M A case with late-onset obsessions and compulsions following chronic cerebral ischemia. Bulletin of Clinical Psychopharmacology 2004.
  68. Agargun MY, Besiroglu L.  Sleep and suicidality: do sleep disturbances predict suicide risk?   Sleep 2005.
  69. Besiroglu L, Agargun MY, Inci R. Nightmares and terminal insomnia in depressed patients with and without melancholic features. Psychiatry Research 2005.
  70. Besiroglu L, Cilli AS, Aşkin R. The predictors of health care seeking behavior in obsessive-compulsive disorder. Comprehensive Psychiatry 2004

 

 

 

 

 

Geliştirdiğimiz ya da Türkçe'ye Uyarladığımız Değerlendirme Araçları

 

  • Padua Envanteri

  • Clark Beck Obsesyonlar ve Kompulsiyonlar Ölçeği

  • Obsesif İnanışlar Ölçeği

  • Obsesyon Kompulsiyon Envanteri

  • Başa Çıkma Tutumlarını Değerlendirme Ölçeği

  • Beyaz Ayı Düşünce Supresyon Ölçeği

  • Boyutsal Yale Brown Obsesyon Kompulsiyon Ölçeği

  • Çocuklar İçin Yale Brown Obsesyon Kompulsiyon Ölçeği

  • Obsesyonel Olasılıklık Çıkarım Ölçeği

  • Temel Yas Unsurları Ölçeği

  • Duygudurum Profili (POMS)

  • Travma Sonrası Stres Bozukluğu Belirtileri Ölçeği-